Timothy R. Carlson

Technical Advisor

Dr. Carlson is a technical advisor with an emphasis in the areas of biotechnology and pharmaceuticals. Recent technologies with which he has been involved include antibodies, nucleic acid sequences and vectors, protein glycosylation, protein conjugation, pharmaceutical formulations, cosmetic formulations, active pharmaceutical ingredient syntheses, and medical therapies. He prepares and prosecutes U.S. and foreign patent applications, and assists in the preparation of patentability, patent landscape, infringement clearance, and validity legal opinions.

Prior to joining Leydig, Voit & Mayer, Dr. Carlson worked as a senior biologist for Abbott Vascular supporting both the drug eluting stent and atherosclerosis research programs. His postdoctoral training took place at the University of California-San Francisco where he developed and analyzed murine models of vascular disease. He received his doctorate from the University of Chicago where his dissertation research focused upon the cellular and molecular mechanisms of angiogenesis. Dr. Carlson received his undergraduate degree in Biology from the University of Illinois at Urbana-Champaign where he worked as a research assistant in the Department of Food Science and Human Nutrition on the virulence factors of Listeria monocytogenes.

Professional Affiliations

•  Intellectual Property Owners Association (IPO)

Articles and Publications

• Miniati D, Jelin EB, Ng J, Wu J, Carlson TR, Wu X, Looney MR, Wang RA. "Constitutively Active Endothelial Notch4 Causes Lung Arteriovenous Shunts in Mice." Am J Physiol Lung Cell Mol Physiol. 2010 Feb; 298(2): L169-77.
• Murphy PA, Wu X, Lam MTY, Kim TN, Vartanian SM, Bollen AW, Carlson TR, Wang RA. “Endothelial Notch4 Signaling Induces Brain Arteriovenous Malformations in Mice.” Proc Natl Acad Sci U S A. 2008 Aug 5; 105(31): 10901-06
• He C, Hu H, Braren R, Fong SY, Trumpp A, Carlson TR, Wang RA. “c-myc in the Hematopoietic Lineage is Critical for its Angiogenic Function in the Mouse Embryo.” Development. 2008 Aug; 135(14): 2467-77
• Carlson TR, Hu H, Braren R, Kim YH, Wang RA. “Cell-Autonomous Requirement for b1 Integrin in Endothelial Cell Adhesion, Migration, and Survival During Angiogenesis in Mice.” Development. 2008 Jun; 135(12): 2193-202
• Carlson TR, Yan Y, Wu X, Lam MT, Tang GL, Beverly LJ, Messina LM, Capobianco AJ, Werb Z, Wang R. “Endothelial Expression of Constitutively Active Notch4 Elicits Reversible Arteriovenous Malformations in Adult Mice.” Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28): 9884-9
• Carlson TR, Feng Y, Maisonpierre PC, Mrksich M, Morla AO. “Direct Cell Adhesion to the Angiopoietins Mediated by Integrins.” J Biol Chem. 2001 Jul 13; 276(28): 26516-25

Honors

• Awarded postdoctoral fellowships from the National Institutes of Health and the American Heart Association
• Awarded scholarships to present graduate work at international scientific conferences

Speaking Engagements and Presentations

• “Endothelial Signaling Pathways in Vascular Development and Vascular Disease: Integrating the Angiopoietins and Notch.” Abbott Laboratories, Abbott Park, IL, 2006
• “Identification of Cell Adhesion Sites in Angiopoietin-1 and Angiopoietin-2.” American Heart Association: 3rd Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology, Salt Lake City UT, 2002
• “Direct Cell Adhesion to the Angiopoietins is Tie(d)2 Integrins.” University of Chicago: Cancer Biology and Human Nutrition and Nutritional Biology Annual Retreat, Delevan, WI, 2001

Bar Admissions and Registrations

• Registered to practice before the U.S. Patent and Trademark Office, 2009

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