Rebecca S. Dise

Technical Advisor

Dr. Dise currently works as a technical advisor with an emphasis in the area of biotechnology. She has experience preparing and prosecuting U.S. and foreign patent applications, and preparing legal opinions including patentability opinions, patent landscape reports, infringement clearance opinions, and validity opinions. She recently has been involved with technologies including human biologics, immunotherapy, antibody technology, gene therapy, nucleic acid and amino acid sequences, siRNA, pharmaceutical compositions and formulations, and medical treatments.

Prior to joining Leydig, Voit, & Mayer, Dr. Dise was a postdoctoral scholar in the Ben May Department for Cancer Research at the University of Chicago. She completed her graduate studies in the Department of Cell and Developmental Biology at Vanderbilt University School of Medicine, where her graduate research focused on tyrosine kinase signaling pathways and cellular migration. For her doctoral dissertation, she investigated the role of epidermal growth factor receptor signaling in intestinal wound healing and repair. As an undergraduate, Dr. Dise worked as a research assistant in the Departments of Chemistry and Biology at the University of Richmond.

Professional Affiliations

• American Association for the Advancement of Science (AAAS)
• Intellectual Property Owners Association (IPO)

Articles and Publications

• Yamaoka T, Frey MR, Dise RS, Bernard JK, Polk DB. Specific epidermal growth factor receptor autophosphorylation sites promote mouse colon epithelial cell chemotaxis and restitution. Am J Physiol Gastrointest Liver Physiol. 2011 May 26.
• Berlin I, Higginbotham KM, Dise RS, Sierra MI, Nash PD. The deubiquitinating enzyme USP8 promotes trafficking and degradation of the chemokine receptor CXCR4 at the sorting endosome. J. Biol Chem. 2010 Nov 26; 285(48): 37895-908.
• Yamaoka T, Yan F, Cao H, Hobbs SS, Dise RS, Tong W, Polk DB. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proc Natl Acad Sci U S A 2008 Aug 19; 105(33); 11772-7.
• Dise RS, Frey MR, Whitehead RH, Polk DB. Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1): G276-85.
• Chen X, Abair TD, Ibanez MR, Su Y, Frey MR, Dise RS, Polk DB, Singh AB, Harris RC, Zent R, Pozzi A. Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol. 2007 May; 27(9): 3313-26.
• Frey MR, Dise RS, Edelblum KL, Polk DB. p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration. EMBO J. 2006 Dec 13; 25(24): 5683-92.
• Shin NY, Dise RS, Schneider-Mergener J, Ritchie MD, Kilkenny DM, Hanks SK. Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration. J Biol Chem. 2004 Sep 10; 279(37): 38331-7.
• Donaldson JC, Dise RS, Ritchie MD, Hanks SK. Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity. J Biol Chem. 2002 Aug 9; 277(32): 29028-35.

Honors

• Received the American Gastroenterological Association Poster of Distinction award, 2005, Digestive Disease Week

Speaking Engagements and Presentations

• Dise RS, Tong W, Polk DB. Epidermal growth factor stimulated intestinal epithelial cell migration requires Rac GTPase activation. Digestive Disease Week, Chicago, IL, May 14-19, 2005. Poster presentation.
• Dise RS, Polk DB. Epidermal growth factor stimulates Rac1 activation in intestinal epithelial cells through Src and PI 3-Kinase to promote cell migration. Digestive Disease Week, Los Angeles, CA, May 20-25, 2006. Oral presentation.
• Dise RS, Berlin I, Sierra M, Marchese A, Nash PD. CXCR4 stability, trafficking and activity are modulated by the deubiquitylating enzyme USP8. Autumn Immunology Conference, Chicago, IL, November 17-20, 2006. Oral and poster presentation.

Bar Admissions and Registrations

• Registered to practice before the U.S. Patent and Trademark Office

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