Francis J. Koszyk

Technical Advisor

Mr. Koszyk works as a technical advisor with an emphasis in the area of pharmaceutical and chemical technologies. Prior to joining Leydig, Voit & Mayer, he worked as a research scientist in the ethical pharmaceutical industry in the area of medicinal chemistry and drug discovery, most recently with Pfizer, Inc. He is co-author of 10 scientific publications, a named inventor on 36 granted U.S. patents, and the agent of record on 10 U.S. issued patents.

Professional Affiliations

• American Chemical Society
  • Member, Business Development and Management and Medicinal Chemistry Divisions
• Intellectual Property Law Association of Chicago (IPLAC)
• Intellectual Property Owners Association (IPO)

Articles and Publications

• Koszyk, F. J. "Synthesis of Substituted Pentalenes and Indenes via Cyclopropanation of Dienic Diazoketones". M. S. Thesis, Illinois Institute of Technology, Chicago, Illinois, 1981.
• Hudlicky, T.; Koszyk, F. J. "Selectivity in Retro-ene vs. Cyclopentene Rearrangements of a cis-Methyl Vinylcyclopropane", Tetrahedron Letters, 1980, 1487.
• Hudlicky, T;. Koszyk, F. J.; Kutchan, T. M.; Sheth, J. "Cyclopentene Annulation via Intramolecular Addition of Diazo Ketones to 1,3-Dienes. Applications to the Synthesis of Cyclopentanoid Terpenes", J. Org. Chem., 1980, 45, 5020.
• Hudlicky, T.; Koszyk, F. J.; Dochwat, D.; Cantrell, G. L. "Intramolecular Cyclopentene Annulation. 2. Synthesis and Carbon-13 Nuclear Magnetic Resonance Spectroscopy of Bicyclo- [4.3.0] non-7-en-2-ones", J. Org Chem., 1981, 46, 2911.
• Govindan, S. V.; Hudlicky, T.; Koszyk, F. J. "Two Topologically Distinct Syntheses of (±) Sarcomycin", J. Org. Chem., 1983, 48, 3581.
• Lenz, G. R.; Koszyk, F. J. "A Biomimetic Synthesis of the Novel 6,7-Oxazine ring-fused Dehydroaporphine Alkaloid Duguendine", J. Chem. Soc., Perkin Trans. I, 1984, 6, 1273.
• Dorn, C. R.; Koszyk, F. J.; Lenz, G. R. "Lead Tetraacetate Oxidation of Oxprotoberberines. A Convenient Synthesis of 13 Oxygenated Berbines and Oxyprotoberberines", J. Org. Chem., 1984, 49, 2642.
• Khanna, I. K.; Koszyk, F. J.; Stealey, M. A.; Weier, R. M.; Julien, J.; Mueller, R. A.; Rao, S.; Swenton, L.; Getman, D. P.; DeCrescenzo, G. A.; Heintz, R. M. "Nucleophilic Opening of N-Carboalkoxy-2,3 Anhydro-1-Deoxymannojirimycin. A Useful Method for the Syntheses of 2-, 3-, and 2,3-Disubstituted 1-Deoxynojirimycin Analogs", J. Carbohydrate Chem., 1995, 14, 843.
• Khanna, I. K.; Weier, R. M.; Yu, Y.; Xu, X. D.; Koszyk, F. J.; Collins, P. W.; Koboldt, C. M.; Veenhuisen, A. W.; Perkins, W. E.; Casler, J. J.; Masferrer, J. L.; Zhang, Y. Y.; Gregory, S. A.; Seibert, K.; Isakson, P. C. "1,2-Diarylimidazoles as Potent, Cyclooxygenase-2 Selective, and Orally Active Antiinflammatory Agents", J. Med. Chem., 1997, 40, 1634.
• Khanna, I.K.; Yu, Y.; Huff, R.M.; Weier, R.M.; Xu, X.; Koszyk, F.J.; Collins, P.W.; Cogburn, J.N.; Isakson, P.C.; Koboldt, C.M.; Masferrer, J.L.; Perkins, W.E.; Seibert, K.; Veenhuizen, A.W.; Yuan, J.; Yang, D C.; Zhang, Y.Y. "Selective Cyclooxygenase-2-Inhibitors: Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents", J. Med. Chem., 2000, 43, 3168.
• Koszyk, F. J.; Partis, R. A.; Mueller, R. A. "Antiviral Compounds and Use Thereof", U. S. Patent 4,876,268, 1989.
• Koszyk, F. J.; Partis, R. A.; Mueller, R. A. "Intermediates for Antiviral Compounds", U. S. Patent 4,937,357, 1990.
• Koszyk, F. J.; Deason, J. R. "2,2-Di-Substituted Benzopyran Leukotriene-D4 Antagonists", U. S. Patent 4,950,684, 1990.
• Koszyk, F. J.; Partis, R. A., Mueller, R. A. "Antiviral Compounds and a Method of Use Thereas", U. S. Patent 4,973,602, 1990.
• Partis, R. A.; Koszyk, F. J.; Mueller, R. A. "1,5-Dideoxy-1,5-Imino-D-Glucitol Derivatives", U. S. Patent 5,003,072, 1991.
• Koszyk, F. J.; Deason, J. R. "2,2-Disubstituted Benzopyran Leukotriene-D4 Antagonists", U. S. Patent 5,093,353, 1992.
• Partis, R. A.; Koszyk, F. J.; Mueller, R. A. "Novel Antiviral Compounds", U. S. Patent 5,144,037, 1992.
• Partis, R. A.; Koszyk, F. J.; Mueller, R. A. "Novel Antiviral Compounds", U. S. Patent 5,221,746, 1993.
• Koszyk, F. J.; Deason, J. R. "2,2-Di-Substituted Benzopyran Leukotriene-D4 Antagonists", U. S. Patent 5, 219,883, 1993.
• Koszyk, F. J.; Mueller, R. A. "2- And 3-Sulfur Derivatives of 1,5 Iminosugars", U. S. Patent 5,268,482, 1993.
• Partis, R. A.; Koszyk, F. J.; Mueller, R. A. "Novel Antiviral Compounds", U. S. Patent 5,310,745, 10 May 1994.
• Koszyk, F. J.; Mueller, R. A. "2- And 3-Sulfur Derivatives of 1,5- Iminosugars", U. S. Patent 5,331,096, 19 July 1994.
• Koszyk, F. J.; Mueller, R. A. "2- And 3-Sulfur Derivatives of 1,5-Iminosugars", U. S. Patent 5,342,951, 30 August 1994.
• Partis, R. A.; Koszyk, F. J.; Mueller, R. A. "Method of Inhibiting Lentivirus", U. S. Patent 5,411,970, 2 May 1995.
• Koszyk, F. J.; Weier, R. A. "Derivatives of Aromatic Cyclic Alkylethers", U. S. Patent 5,420,343, 30 May 1995.
• Mueller, R. A.; Partis, R. A.; Koszyk, F. J.; Barta, T. E.; McKearn, J. P.; Gregory, S. A. "Halogenated Phenylacetonitrile Alkylaminoalkylphenyl Compounds as Immunosuppressives", U. S. Patent 5,451,604, September 1995.
• Partis, R. A.; Mueller, R. A.; Koszyk, F. J.; Weier, R. M. "Derivatives of Cyclic Phenolic Thioethers", U. S. Patent 5,476,859, December 1995.
• Khanna, I. K.; Weier, R. M.; Collins, P. W.; Yu, Y.; Xu, X.; Huff, R. M.; Partis, R. A.; Koszyk, F. J. "1,2-Substituted Imidazolyl Compounds for the Treatment of Inflammation", U. S. Patent 5,616,601, 1 April 1997.
• Koszyk, F. J.; Partis, R. A.; Weier, R. M. "2,3-Substituted Pyridines for the Treatment of Inflammation", U. S. Patent 5,686,470, 11 November 1997.
• Chen, B.B.; Chen, H. Y.; Clare, M.; Docter, S. H.; Khanna, I. K.; Koszyk, F. J.; Malecha, J. W.; Miyashiro, J. M.; Penning, T. D.; Rico, J. G.; Ruminski, P. G.; Russell, M. A.; Weier, R. M.; Xu, X.; Yu, S. S.; Yu, Y., "Cinnamic Acid Derivatives", U. S. Patent 5,852,210, 22 December 1998.
• Weier, R. M.; Lee, L. F.; Partis, R. A.; Koszyk, F. J.,"2,3-Substituted Pyridines for the Treatment of Inflammation", U. S. Patent 5,916,905, 29 June 1999.
• Mueller, R. A.; Barta, T. E.; McKearn, J. P.; Gregory, S. A.; Partis, R. A.; Koszyk, F. J., "Halogenated Phenylacetonitrile Alkylaminoalkylphenyl Compounds as Immunosuppressives", U. S. Patent 6,265,439, 24 July 2001.
• Anantanarayan, A.; Clare, M.; Collins, P.W.; Crich, J.Z.; Devraj, R.; Flynn, D.L.; Geng, L.; Graneto, M.J.; Hanau, C.E.; Hanson, G.J.; Hartmann, S.J.; Hepperle, M.; Huang, H.; Koszyk, F.J.; Liao, S.; Metz, S.; Partis, R.A.; Perry, T.D.; Rao, S.N.; Selness, S.R.; South, M.S.; Stealey, M.A.; Talley, J.J.; Vasquez, M.L.; Weier, R.M.; Xu, X.; Khanna, I.K.; Yu, Y. "Substituted Pyrazoles as p38 Kinase Inhibitors", U.S. Patent 6,423,713, 23 July 2002.
• Anantanarayan, A.; Clare, M.; Collins, P.W.; Crich, J.Z.; Devraj, R.; Flynn, D.L.; Geng, L.; Graneto, M.J.; Hanau, C.E.; Hanson, G.J.; Hartmann, S.J.; Hepperle, M.; Huang, H.; Koszyk, F.J.; Liao, S.; Metz, S.; Partis, R.A.; Perry, T.D.; Rao, S.N.; Selness, S.R.; South, M.S.; Stealey, M.A.; Talley, J.J.; Vasquez, M.L.; Weier, R.M.; Xu, X.; Khanna, I.K.; Yu, Y. "Substituted Pyrazoles as p38 Kinase Inhibitors", U.S. Patent 6,514,977, 4 February 2003.
• Anantanarayan, A.; Clare, M.; Collins, P.W.; Crich, J.Z.; Devraj, R.; Flynn, D.L.; Geng, L.; Graneto, M.J.; Hanau, C.E.; Hanson, G.J.; Hartmann, S.J.; Hepperle, M.; Huang, H.; Koszyk, F.J.; Liao, S.; Metz, S.; Partis, R.A.; Perry, T.D.; Rao, S.N.; Selness, S.R.; South, M.S.; Stealey, M.A.; Talley, J.J.; Vasquez, M.L.; Weier, R.M.; Xu, X.; Khanna, I.K.; Yu, Y. "Substituted Pyrazoles as p38 Kinase Inhibitors", U.S. Patent 6,525,059, 25 February 2003.
• Khanna, I.K.; Weier, R. M.; Collins, P, W.; Yu, Y.; Xu, X.; Partis, R. A.; Koszyk, F. J.; Huff, R. M. "Heterocyclo-substituted imidazoles for the treatment of inflammation", U. S. Patent 6,613,789, 2 September 2003.
• Naraian, A. S.; Clare, M.; Collins, P. W.; Crich, J. Z.; Devraj, R.; Flynn, D. L.; Geng, L.; Graneto, M. J.; Hanau, C. E.; Hanson, G. J.; Hartmann, S. J.; Hepperle, M.; Huang, H.; Koszyk, F. J.; Partis, R. A.; Perry, T. D.; Rao, S. N.; Selness, S. R.; South, M. S.; Stealey, M. A.; Talley, J. J.; Vazquez, M. L.; Weier, R. M.; Xu, X.; Khanna, I. K.; Yu, Y. "Substituted Pyrazoles as p38 Kinase Inhibitors", U. S. Patent 6,617,324, 9 September 2003.
• Bergmanis, A.A. et al, "Substituted pyrazolyl compounds for the treatment of inflammation," U.S. Patent 6,979,686m 18 October 2005.
• Narain, A.S. et al, "Substituted pyrazoles as p38 kinase inhibitors," U.S. Patent 6,979,686, 27 December 2005.
• Narain, A.S. et al, "Substituted pyrazoles as p38 kinase inhibitors," U.S. Patent 7,071,198, 4 July 2006.
• Narain, A.S. et al, "Substituted pyrazoles as p38 kinase inhibitors," U.S. Patent 7,153,959, 26 December 2006.
• Bergmanis, A.A. et al., "Substituted pyrazolyl compounds for the treatment of inflammation," U.S. Patent 7,186,743, 6 March 2007.
• Khanna, I.K. et al., "Heterocyclo-substituted imidazoles for the treatment of inflammation," U.S. Patent 7,220,770, 22 May 2007.
• Carter, J. et al., "Benzopyran compounds useful for treating inflammatory conditions," U.S. Patent 7,259,266, 21 August 2007.

Bar Admissions and Registrations

• Registered to practice before the U.S. Patent and Trademark Office

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