Derek W. Barnett

Technical Advisor

Dr. Barnett is a technical advisor with an emphasis in the areas of chemistry and biotechnology. Prior to joining Leydig, Voit & Mayer, he received his doctorate from the College of Pharmacy at The Ohio State University, where he held graduate research and teaching positions in the Division of Medicinal Chemistry and Pharmacognosy. His doctoral dissertation describes his work on synthetic strategies for the production of stable-isotope labeled amino acids and the synthesis of small-molecule affinity labels for studying the biological activity of vitamin A derivatives. Before his postgraduate studies, Dr. Barnett received his undergraduate degree from the University of Arkansas at Little Rock where he was a research assistant in the Department of Chemistry.

Professional Affiliations

• American Chemical Society – divisions of Medicinal Chemistry and Chemistry & the Law
• Intellectual Property Owners Association (IPO)

Articles and Publications

• "The unhydrolyzable fenretinide, 4-HBR, induces the proapoptotic genes GADD153 (CHOP) and BBC3 (PUMA) and apoptosis that is caspase-dependent and independent of the retinoic acid receptor," Cancer Research, 67: 6270-7 (2007).
• "Stereoselective route to 15N-labeled-β-deuterated amino acids:  synthesis of (2S,3R)-3-2H,15N]-phenylalanine," Tetrahedron: Asymmetry, 13: 1893-1900 (2002).
• "Solid phase synthesis of arylretinamides", U.S Patent Application Publication No. 2004/0102650, (patent pending).
• "Synthesis of (2S,3S)-3-2H,15N]-tyrosine: facilitation by novel hexachloroacetone/polymer-supported triphenylphosphine chlorination conditions," (manuscript in preparation).

Speaking Engagements and Presentations

• "Isotopically labeled amino acids: stereochemical implications of hexachloroacetone/polymer supported triphenylphosphine chlorination of chirally deuterated benzylic alcohols," 224th National Meeting of the American Chemical Society, Boston, MA, MEDI 404, (2002).
• "Photo/affinity label analogs of N-(4-hydroxyphenyl)retinamide," 224th National Meeting of the American Chemical Society, Boston, MA, MEDI 143 (2002).
• "Towards a general approach to stereoselectively β-deuterated and 15N-labeled amino acids: synthesis of (2S,3S)-3-2H,15N]-phenylalanine," 218th National Meeting of the American Chemical Society, New Orleans, LA, MEDI 255, (1999).
• "Synthetic efforts toward the stereoselective synthesis of β-deuterated amino acids for studies of protein structure by multidimensional NMR," 36th National Organic Chemistry Symposium, Madison, WI, (1999).

Bar Admissions and Registrations

• Registered to practice before the U.S. Patent and Trademark Office

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